Additionally, the higher level of 4EBP1 phosphorylation at Thr70 sites (4EBP1_pT70) in malignant melanoma was associated with a worse prognosis (O'Reilly et al., 2009) and the increase of 4EBP1 phosphorylation at Thr46 sites (4EBP1_pT46) associated with poor prognosis in hepatocellular carcinoma (Lin et al., 2020). The gene discussed is EIF4EBP1; the disease is melanoma.