EIF4EBP1 and neoplasm: 4EBP1 is generally considered as a tumor suppressor (Moerke et al., 2007; Martineau et al., 2013; Musa et al., 2016; Wang et al., 2019) involved in the inhibition of the translation and synthesis of multiple classic oncogenic proteins, such as CDK1, HIF-1α, VEGF-A, and MYC (Dodd et al., 2015; Choi et al., 2019; Batool et al., 2020; Haneke et al., 2020).