In a variety of urinary system tumors, such as bladder urothelial carcinoma (BLCA) and kidney cancer (KICH and KIRC), 4EBP1 was positively correlated with the degree of CAFs infiltration, while in digestive system malignancy, such as colon adenocarcinoma (COAD), rectum adenocarcinoma (READ) and stomach adenocarcinoma (STAD), it was negatively correlated. The gene discussed is EIF4EBP1; the disease is kidney cancer.