Many prominent up-regulation pathways related to tumor progression and development were discovered in high-SPI HNSCC patients compared to the low-SPI group, including EMT signaling, MYC targets v1, E2F targets, mTORC1 signaling, hypoxia signaling, MYC targets v2, angiogenesis, G2M checkpoint, and glycolysis. The gene discussed is MYC; the disease is neoplasm.