GSEA results revealed that some signaling pathways, such as epithelial mesenchymal transition (EMT), MYC targets v1, E2F targets, mTORC1 signaling, hypoxia, MYC targets v2, angiogenesis, G2M checkpoint, and glycolysis, were up-regulated in the high-SPI group of HNSCC (false discovery rate < 0.25) (Figure 6C). This evidence concerns the gene MYC and head and neck squamous cell carcinoma.