MiR-92a (potentially sponged by hsa_circ_0024722, hsa_circ_0059965, and hsa_circ_0062949) and miR-221/222 (potentially sponged by hsa_circ_0139214 and hsa_circ_0108959) participated in the course of atherosclerosis by targeting KLF2 mRNA, which modulates shear stress genes (Wu et al., 2011), and sustaining plaque stability (Bazan et al., 2015), respectively. The gene discussed is KLF2; the disease is atherosclerosis.