Furthermore, miR-298 (potentially sponged by hsa_circ_0097102 and hsa_circ_0014293) exacerbated cerebral ischemia/reperfusion injury by targeting ACT1 mRNA (Sun et al., 2018), while miR-210 (potentially sponged by hsa_circ_0140265 and hsa_circ_0040760) targets CASP8AP2 mRNA and ISCU1/2 mRNA to suppress apoptosis and improve cerebral injury following AIS (Chan et al., 2009; Kim et al., 2009). The gene discussed is CASP8AP2; the disease is brain ischemia.