Here, we found 20 DGCs and 35 ICGs to be highly differentially expressed across the three HCC subtypes, of which 4 DGCs (CCND1, CYP2E1, G6PC and TERT) and eight ICGs (CD80, LDHA, PVR, TNFSF4, CD40, CD40LG, LGALS9 and PTPRC) also correlated with prognosis. This evidence concerns the gene CYP2E1 and hepatocellular carcinoma.