Here, we found 20 DGCs and 35 ICGs to be highly differentially expressed across the three HCC subtypes, of which 4 DGCs (CCND1, CYP2E1, G6PC and TERT) and eight ICGs (CD80, LDHA, PVR, TNFSF4, CD40, CD40LG, LGALS9 and PTPRC) also correlated with prognosis. The gene discussed is CD40; the disease is hepatocellular carcinoma.