On the other hand, patients with combined high ERβ + negative ERα expression had higher IRSs for CysLT2R (P < 0.001), membrane β-catenin (P < 0.001), 15-PGDH (P < 0.01) and PGD2 synthase (P < 0.001), which are associated with a better outcome in CRC (20, 23, 33, 34) (Figure 6A, Supplementary Figure 3). Here, ESR1 is linked to colorectal carcinoma.