ESR2 and cancer: The Cox regression analysis showed that patients with combined high ERβ + negative ERα expression were independently associated with better OS and had a 77% reduction in overall mortality (Figures 4A,B, Supplementary Table 1), as well as better DFS with a 90% reduction in cancer recurrence (Figures 4C,D, Supplementary Table 1) after adjustment for age, TNM stage and tumor vascular invasion, compared to patients with combined low ERβ + positive ERα expression, which were taken as the reference group.