ESR2 and colorectal carcinoma: Likewise, in the TCGA-COAD cohort, low ERα protein expression (HR = 0.73; 95% CI, 0.62-0.92; P = 0.035, Figure 3B) and high ERβ protein expression (HR = 0.78; 95% CI, 0.68-0.89; P = 0.001, Figure 3C) are associated with better prognosis of CRC patients.