In KEGG pathway analysis, 7 significant pathways closely related to the pathogenesis or treatment of hypertension were found: neuroactive ligand-receptor interaction, calcium signaling pathway, HIF-1 signaling pathway, TNF signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, and PI3K-Akt signaling pathway. The gene discussed is HIF1A; the disease is Hypertension.