For instance, according to Dong et al. [37], silencing of Nrf2 expression in H9C2 cells led to insufficient production of antioxidant enzymes by aldehyde for reversing oxidative damage led by tert-butyl hydrogen peroxide (TBHP) and hence greatly increases the chances of arrhythmia. The gene discussed is NFE2L2; the disease is cardiac arrhythmia.