SIRT1 and acute myocardial infarction: For instance, after acute myocardial infarction, the exosomes obtained through adipose tissue-derived mesenchymal stem cells (AMSCs) upregulating sirtuin 1 (SIRT1) were found to reduce infarct size and atrial fibrotic area [10], whereas it is evident that the BMSC-derived exosomal microRNA-185 can inhibit ventricular remodeling in mice with myocardial infarction [11].