Besides, it was demonstrated that delivery of exosomes from the BMSCs overexpressing Nrf2 increased the Nrf2 and HO-1 expression and hence effectively inhibited changes in heart rhythm and shortened the AF duration, confirming that exosomes from Lv-Nrf2 BMSCs promoted recovery of arrhythmias in AF rats. The gene discussed is HMOX1; the disease is cardiac arrhythmia.