The coexisting overexpression of GFAP and CRYAB has been shown for Rosenthal fibers in Alexander’s disease, chronic glial scars, and low- and high-grade fibrillar astrocytomas (Der et al., 2006; Hagemann et al., 2006; Goplen et al., 2010; Sosunov et al., 2017). This evidence concerns the gene GFAP and Alexander disease.