CRYAB and Cerebral ischemia: Although most studies have indicated that many diseases cause CRYAB overexpression in astrocytes, studies of cerebral ischemia in murine models (Piao et al., 2005; Li et al., 2012) showed an early expression of CRYAB in pyramidal neurons of the cerebral cortex during the first hours after occlusion of the middle cerebral artery and reperfusion.