After exposure to 3,5-diethoxycarbonyl-1.4-dihydrocollidine (DDC), myeloid-specific CD39−/− mice manifested worse liver fibrosis compared to wild-type mice, indicating CD39 myeloid expression is protective in sclerosing cholangitis (Rothweiler et al., 2019). The gene discussed is ENTPD1; the disease is sclerosing cholangitis.