P2RX7 and neoplasm: Among these, P2X5, was found elevated in human PDAC and associated with malignant behavior of cancer cells; however, the role of P2X5 in pancreatitis and tumor development is not yet well stablished (Zaccagnino et al., 2016) and there remains uncertainty regarding the role of P2X7 in pancreatitis and PDAC initiation.