In pancreatic cancer, adenosine generation mediated by the concerted activity of CD39 and CD73 is correlated with lower infiltration of CD8+ T cells and γδ+ T cells, as well as stellate cell proliferation and collagen production (Künzli et al., 2008; Chen et al., 2020; Shevchenko et al., 2020). Here, CD8A is linked to familial pancreatic carcinoma.