In vitiligo patients, high IFN-γ expression has been implicated in an aggressive and permanent IS response (IFN-γ→ CXCL10 (C-X-C Motif Chemokine Ligand 10) → CD8+ T cells) (Xie et al., 2016) targeting the population of epithelial cells throughout the body causing visual (Agarwala and Malkud, 2020), hearing (Ma et al., 2021) and vascular dysfunction (Azzazi et al., 2021). The gene discussed is CD8A; the disease is vitiligo.