The nuclear factor E2 related to factor 2-antioxidant/heme oxygenase 1 response element (Nrf2-ARE/HO-1), a key metabolic pathway for genetic signaling transduction of enzymes related to the antioxidant system, is impaired in vitiligo patients (Jian et al., 2014). The gene discussed is HMOX1; the disease is vitiligo.