IFNG and vitiligo: It is plausible that excessive ROS from other metabolic disorders (such as obesity, insulin resistance, and elevated LDL-cholesterol and low HDL-cholesterol) can induce a state of chronic low-grade inflammation (e.g., raising IFN-γ and TNF-α), possibly aggravating or activating vitiligo in genetically predisposed individuals, as illustrated in Figure 1.