NR3C2 and endothelial dysfunction: Because over-activation of the MR/ALDO signaling pathway has been associated with vascular dysfunction (Schiffrin, 2006); it is thus reasonable to consider that either the chronic exposure to pathological levels of ALDO or the increased expression of vascular MR might promote vascular damage, endothelial dysfunction, and altered vasorelaxation (Virdis et al., 2002; Pu et al., 2003; Schiffrin, 2006; Nguyen Dinh Cat et al., 2010).