SERPINE1 and endothelial dysfunction: • Patients with hypertension are in a hypercoagulative and potentially prothrombotic state. This increased thrombotic risk has primarily attributed to the endothelial dysfunction associated with hypertension.• Additionally, hypertension frequently presents with elevations in hemostatic factors such as P-selectin (platelet aggregator), fibrinogen, and PAI-1 (Yang et al., 2010).