SERPINE1 and endothelial dysfunction: • Patients with DM type 1 or type 2 are at increased risk of DVT due to systemic changes and endothelial dysfunction (Diabetes, 2019).• Hyperglycemia triggers vascular damage by an imbalance between nitric oxide (NO) and reactive oxidative species (ROS), platelet aggregation, inflammation, and increased expression of coagulant tissue factors like PAI-1 (Paneni et al., 2013; Kaur et al., 2018).