ALB and Parkinson disease: Indeed, a dysfunctional BBB has been demonstrated in a number of different PD models showing leakage of albumin and other tracers into the brain parenchyma (Carvey et al., 2005, 2009; Westin et al., 2006; Zhao et al., 2007; Chen et al., 2008), increased entry of drugs (Carta et al., 2006; Westin et al., 2006) and infiltration of peripheral immune cells otherwise are prevented from crossing the BBB (Benner et al., 2008; Brochard et al., 2009; Reynolds et al., 2010).