We have examined the interactions of type 2 diabetes (DMT2) and PD at the microvascular interface and shown that DMT2 in combination with a PD lesion resulted in a significant depletion of pericytes, and reduced interactions between microvessels and perivascular microglia which was associated with a lack of the angiogenic response seen in toxin-induced models (Elabi O. F. et al., 2021). Here, SGCG is linked to Parkinson disease.