However, platelet BACE1, combined with A-disintegrin and metallopeptidase 10 (ADAM10) and presenilin 1 (PSEN1), showed high diagnostic value (AUC = 0.9) and high sensitivity (88.9%) for discriminating patients with AD from controls (Bram et al., 2019). The gene discussed is BACE1; the disease is Alzheimer disease.