These results suggest the potential use of p-tau181 as first line of testing to identify patients likely to be tau-positive when tested by PET or CSF biomarkers, either to distinguish AD from other non-AD neurodegenerative diseases in cases with mild to moderate dementia or predict future development of AD in cases with MCI (Janelidze et al., 2020). The gene discussed is MAPT; the disease is neurodegenerative disease.