MAPT and prion disease: Comparative studies on CSF protein biomarkers of neurodegeneration showed that prion RT-QuIC had higher diagnostic accuracy than 14-3-3 and tau tests for prion diseases (McGuire et al., 2016; Foutz et al., 2017; Lattanzio et al., 2017; Hermann et al., 2018; Fiorini et al., 2020).