CDK5 and Parkinson disease: Up regulation of CDK5 can increase the expression of BRCA1-BRCA2 containing complex subunit 3 (BRCC3) in HEK293 cells, while inhibition of CDK5 reduces the up-regulated BRCC3 level in 1-methyl-4-phenylpyridinium (MPP +) induced PD cell model (Cheng et al., 2020).