Rodríguez-García and collaborators [7] provided evidence of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate 3 (PFKFB3) involvement in glycolysis upregulation, in response to TGF-β1 in glioblastoma cells, which is mediated by Smad, p38 MAPK, and PI3K/Akt signaling. This evidence concerns the gene AKT1 and glioblastoma.