In addition, both alcohol itself, as well as withdrawal effects of alcohol can act as acute stressors, leading to changes in corticotropin-releasing factor, and glucocorticoid dysregulation (Koob, 2008; Béracochéa et al., 2019; Hupalo et al., 2019b), which can in turn manifest as cognitive deficits. Here, CRH is linked to Cognitive impairment.