In epilepsy models, Nrf2 expression reduction has been observed (Geng et al., 2018), but the ablation of the Nrf2 gene also enhances the degradation of IκBα, which leads to increased activation of the NF-κB protein and further upregulation of the expression of pro-inflammatory cytokines (Thimmulappa et al., 2006). Here, NFE2L2 is linked to epilepsy.