Singh et al. concluded that NF-κB activation in neurons during epilepsy can promote the expression of B-cell lymphoma-2 (Bcl2) (Singh and Singh, 2020), and Mattson et al. showed that manganese-superoxide dismutase and Bcl2, which were necessary for neuronal plasticity and physical activity, were the target genes of NF-κB (Mattson and Camandola, 2001). The gene discussed is NFKB1; the disease is epilepsy.