Work with the anti-NGF AD11 mouse model (Ruberti et al., 2000), in which the expression of antibodies against mature NGF in the adult brain causes a progressive neurodegeneration which is similar to that observed in AD brains, provided the first demonstration that deficits in NGF signaling may lead to a Alzheimer-like neurodegeneration (Capsoni et al., 2011), which is broader than a pure cholinergic deficit. Here, NGF is linked to Alzheimer disease.