PTX3 and periodontal disorder: Pentraxin-3, has also been suggested to be a key biomarker for periodontal disease diagnosis (Kathariya et al., 2013), which is supported by our previous findings that salivary levels of pentraxin-3 in combination with specific ASVs (belonging to Streptococcus sp., Selenomonas sp., and Treponema spp).