Our data showed that several inflammatory mediators were increased in RA-periodontitis saliva as compared to non-RA, including TWEAK/TNFSF12, pentraxin-3, IL-19, IL-35, gp130/sIL6Rb, sIL-6Ra, IFN-α2 and sTNF-R1. The gene discussed is PTX3; the disease is periodontitis.