Further, the humanized mouse strain with induced human ACE2 expression, K18-hACE2 mice from Jackson labs, (McCray Jr et al., 2007) were shown to support SARS-CoV-2 replication in respiratory and brain tissues, and the authors showed that the model recapitulate many of the findings observed in patients with COVID-19 including changes in the expression of pro-inflammatory molecules similar to what have been observed in patients with COVID-19 post infection. Here, ACE2 is linked to COVID-19.