PITX1 and colonic neoplasm: It is worth mentioning that bacterial biofilms composed mainly of E. coli pks+ and ETBF are found in the mucosa of patients with familial adenomatous polyposis (FAP) and that a synergistic effect of the two toxins (bft and pks) driving the development of colon tumor was demonstrated in ApcMinD716/+ (Dejea et al., 2018).