Cer d18:1/16:0, Cer d18:1/22:0, Cer d18:1/24:0, and Cer d18:1/24:1 were the major contributors to this increase (Figure 5A) Contrastingly, the WT-HF and TRPC1 -/- -HF arms exhibited decreased Cer concentration with increasing gestational age, as well as a decrease in total HexCer concentration. The gene discussed is TRPC1; the disease is hydrops fetalis.