Indirect admission is associated with higher risk features at the time of FMC (older age, female gender, Killip class ≥2, diabetes, hypertension, later presentation), different FMC characteristics (lower rates of national EMS number call, higher rates of paramedics-EMS and self-presentation to ED or to a private MD), pre-CCL medication (lower rates of newer P2Y12 inhibitors and anticoagulation) and in-hospital and procedure characteristics (higher rates of GP2B3A inhibitors and anticoagulation and, lower rates of transradial approach and successful PCI). This evidence concerns the gene P2RY12 and diabetes mellitus.