There is an association between atrial cardiopathy biomarkers and occurrence of stroke, such as increased p-wave terminal force V1 (PTFV1) (9) on the electrocardiography (ECG), left atrial enlargement (10, 11), increased N-terminal pro-B-type natriuretic peptide (NT-proBNP) (12) in serum. The gene discussed is NPPB; the disease is Stroke.