Surprisingly, while transcriptomic profiles of AngII-treated organs/tissues are available in the kidneys (18), heart (19), or abdominal aortic aneurysm in ApoE-/- mice (20), the AngII treatment protocol varies widely between studies, and transcriptomic data on the arterial tissue of WT mice were rarely reported (21–23), with no attempt to analyze any legacy effect. The gene discussed is APOE; the disease is abdominal aortic aneurysm.