Other studies have analyzed the association between mood disorders and diabetes and CVD (including hypertension and CAD) from a genetic perspective (26), finding that depression, diabetes, and CVD may have multiple shared potential pleiotropic genes, thus affecting multiple signaling pathways such as corticotropin-releasing hormone (CRH), adenosine monophosphate activated protein kinase (AMPK), and 5 hydroxytryptamine (5-HT) pathways. Here, CRH is linked to major depressive disorder.