To trace the cellular origin of IFN-γ in CVID, we subsequently employed mass cytometry and found that the circulating IFN-γ+ cells had markers of innate lymphoid cell type 3 (ILC3; lineage negative, CD127+, CD161+, T-bet+, and retinoid acid-related protein receptor-γ+) (27). The gene discussed is IFNG; the disease is common variable immunodeficiency.