We also identified the VEGF signaling pathway network via CellChat analysis and confirmed that TREM2+ LAM-like cells were prominent sources of VEGF ligands interacting with receptors expressed on endothelial cells (Supplementary Figure 6B), suggesting the importance of TREM2+ macrophage-mediated VEGF signaling in promoting angiogenesis in HCC. Here, TREM2 is linked to hepatocellular carcinoma.