IGHE and asthma: In this regard, small studies show that B cell depletion with anti-CD20 (rituximab) reduces steroid dependence in asthma associated with eosinophilic granulomatosis with polyangiitis (Churg–Strauss syndrome), and significantly reduces atopic dermatitis where a reduction in IL-13 production, but not IgE, was observed (46, 47).