Finally, a detailed observation of pancreatic tissue sections stained for insulin, glucagon, and MDA5 revealed that such structures were present exclusively in T1D-RO donors (both DiViD and nPOD) but absent in T1D-LS (EUnPOD) or in nondiabetic control donors (both EUnPOD and nPOD). Here, INS is linked to type 1 diabetes mellitus.