In support of a role of inflammation in promoting islet dedifferentiation and appearance of MDA5-positive/hormone-negative endocrine cells, we observed that one of the highest frequencies of MDA5-positive/hormone-negative islet-like clusters was detected in the pancreas of T1D DiViD case-3, which also showed a high rate of inflammation, thus corroborating the current view of an inflammation-driven mechanism of dedifferentiation induction. Here, IFIH1 is linked to type 1 diabetes mellitus.