Interestingly, an additional analysis of MDA5-glucagon and MDA5-insulin colocalization rate in T1D-RO and T1D-LS performed taking into consideration ICIs and IDIs separately revealed that in IDIs, the colocalization rate of MDA5-glucagon was higher with respect to ICIs (Figure 1C). The gene discussed is GCG; the disease is type 1 diabetes mellitus.