IFIH1 and type 1 diabetes mellitus: Against this background, we presently analyzed MDA5 expression distribution using the multiplex immunofluorescence technique in human pancreatic tissues obtained from nondiabetic (autoantibody-negative as well as autoantibody-positive) and T1D donors from three different organ donor biorepositories (EUnPOD, nPOD, and DiViD study), uncovering qualitative and quantitative differences in the pattern of MDA5 expression occurring in T1D vs nondiabetic pancreas.