IFIH1 and type 1 diabetes mellitus: In order to evaluate the distribution and eventual heterogeneity of pancreatic islets in terms of MDA5 expression, we performed a whole slide scanning imaging analysis of pancreatic tissue sections derived from EUnPOD nondiabetic donors and from T1D DiViD cases, stained for insulin, glucagon, and MDA5 (Figure 3A, panel A).