AKT1 and posterior cortical atrophy: The results of KEGG analysis showed that key mDEGs were enriched in synapse pathways, energy metabolic pathways (PI3K-AKT, MAPK, and PARP), drug metabolism pathways, cholesterol metabolism pathways, endocrine resistance, and steroid hormone biosynthesis pathways, which were associated with PCa development (such as neuroendocrine transformation and CRPC progression).