CDH1 and Alzheimer disease: Interestingly, KLRG1 ligation by E-cadherin reduces IL-5 and IL-13 production by human ILC2s, implicating dysregulation of parenchymal-ILC interactions in AD where E-cadherin levels are canonically downregulated on keratinocytes and ILC2s have elevated KLRG1 expression (132).