Studies have shown that aberrant activation of several signaling pathways, such as Wnt/β-catenin (14), p53/p21 (14), PI3K/Akt (15), PTEN/Akt-p27 (16), and JAK-STAT (11), is involved in the aging process of MSCs in SLE. The gene discussed is AKT1; the disease is systemic lupus erythematosus.