TNFSF13B and systemic lupus erythematosus: Severe proteinuria and mortality were shown to be significantly reduced in BAFF-deficient 6–7-month-old NEM mice (32), in addition, BAFF transgenic (Tg) mice showed a large increase in the number of mature B cells and effector T cells, similar to human SLE, anti-dsDNA antibodies, and immunoglobulin deposits in the kidney (33).