Whereas most infections are asymptomatic or mildly symptomatic, SARS-CoV-2 can trigger an explosive inflammatory response (cytokine storm) primarily mediated by IL-6, C-X-C motif chemokine 10 (CXCL10), and type 1 interferon, leading to acute respiratory distress syndrome (71). The gene discussed is CXCL10; the disease is infection.