Anti-inflammation (downregulation of CX3CL1, reduction in CD68+ macrophages infiltration) and decreased renal fibrosis (reduction of α-SMA).Downregulated CX3CL1 was associated with specific miRNAs in EVs (miR-15a, miR-15b, mi-R16). The gene discussed is CX3CL1; the disease is renal fibrosis.