For example, JMJD6 not only had intrinsic tyrosine kinase activity but also phosphorylated Y39 of histone H2A.X (H2A.XY39ph) in triple negative breast cancer (TNBC) cells, then autophagy regulated by JMJD6- H2A.XY39ph axis promoted cell growth (37). This evidence concerns the gene JMJD6 and triple-negative breast carcinoma.