To further understand the immunomodulatory role of JMJD6 in cancer, we downloaded the TCGA Pan-Cancer dataset (TCGA Pan-Cancer (PANCAN, N (TCGA sample number) =10535, G (ENSG ID number) =60499)) from the UCSC database (https://xenabrowser.net/)), and extracted the expression data of JMJD6 and 150 immunoregulatory genes, 60 immune checkpoint-related genes as well as 22 tumor-associated immune cells in pan-cancers. This evidence concerns the gene JMJD6 and cancer.