Interestingly, JMJD6 co-overexpression with c-Myc synergistically triggered malignant phenotype, EMT and even metastasis in breast cancer as well as resulted in poor prognosis of ER+ breast cancer patients (32), suggesting it may be an important target of Myc-driven tumorigenesis and malignant progression of breast cancer. The gene discussed is MYC; the disease is breast carcinoma.