Bioinformatics analysis results uncovered that JMJD6 was negatively associated with a series of immunoregulatory genes (i.e., CCXL2, CCL22, CCL25, CCL14, CCL16, CXCL9-12, etc) in LUSC, HNSC, UCS, MESO, THYM, DLBC, UCEC, LIHC, and SARC (Figure 4A), and was negatively correlated with most tumor-infiltrating immune cells (i.e., plasma cells, CD8+ T cells, resting memory CD4+ T cells, gamma delta T cells, activated NK cells, monocytes, M1 macrophages, and dendritic cells) in pan-cancer (Figure 4B). The gene discussed is CD4; the disease is cancer.