Most of these TAAs such as triosephosphateisomerase 1 (TPIS), glucose-6-phosphate-dehydrogenase (G6PD), isocitrate-dehydrogenase (IDHC), keratin 10 (K1C10), cofilin-1 (COF1) and transgelin (TAGL) were also up-regulated in PDAC tissue suggesting an attempt of the immune system to target molecules involved in tumor metabolism and metastasis (89). This evidence concerns the gene G6PD and neoplasm.