rs2151280 TT genotype associated with poorer overall survival in adult patients with hematologic malignancies after allo-HSCT.rs2151280 TT → ↑ ANRIL in PBMC → ↓ P-15, P-16, and ARF → Negatively affect P53-dependent apoptosis and pRB-mediated cell cycle control. This evidence concerns the gene RB1 and hematologic disorder.