As shown in Figure 3D, overexpression of hub DEGs (CD38, CDMK2, TBC19) was highly enriched in pathways related to T cell/B cell receptor signaling pathways, primary immunodeficiency, NK cell-mediated cytotoxicity, cytokine–cytokine receptor interaction, and the JAK/STAT signaling pathway (p < 0.05). Here, CD38 is linked to inborn error of immunity.