MAF and neoplasm: Through ChIP-sequencing analysis, c-MAF was shown to directly regulate Csf-1r transcription and control important M2 markers as Il12, Il1b, Il6, Arg1, Il10, Tgfb, Irf4, and Ccr2. This study further demonstrated that c-MAF may act as a metabolic switch in macrophage inhibiting the glycolysis and promoting the TCA cycle and UDP-GlcNAc activity to favor macrophage conversion into immunosuppressive M2 within the tumor suggesting an important role of MAF on cell metabolic activity (119).