Interestingly similar observations were made in diffuse large B-cell lymphoma (DLBCL) showing that STAT3 and NFAT2 interaction induced an immunoregulatory phenotype in malignant B cells with the upregulation of IL-10 and programmed Death-Ligand 1 (PDL1) (86). This evidence concerns the gene CD274 and diffuse large B-cell lymphoma.