ASPG and acute lymphoblastic leukemia: The BFM and COALL ALL study groups reported a prospective study of 420 patients (BFM n = 300, COALL n = 120), that confirmed the higher thrombosis incidence with concomitant administration of asparaginase and steroids (BFM 11.6%, COALL 2.5%) (OR 7.7 p = 0.05) (16).