The mutant messenger RNA should presumably produce a peptide consisting of 16 amino acids at the N-terminus, with 21 novel amino acids on the heels of the wild-type protein.<h4>Conclusions</h4>Our study expands on the spectrum of <i>GPIHBP1</i> variants and contributes to a more comprehensive understanding of the genetic diagnosis, genetic counseling, and multimodality therapy of families with severe hyperlipidemia. This evidence concerns the gene GPIHBP1 and hyperlipidemia.