PLK4 and type 2 diabetes mellitus: Besides, HOTAIR upregulates a number of genes associated with cell cycle, including checkpoint kinase 1 (CHEK1), cyclin A2 (CCNA2), cyclin B2 (CCNB1), serine/threonine-protein kinase (PLK4), active-state power management (ASPM), and non-SMC condensin I complex subunit G (NCAPG), which was previously shown to be linked to T2DM development [43].