For the following review of PCH mode of action, it is worth mentioning that hyperinsulinemia and hyperglycemia in NAFLD induce SREBP-1c (sterol regulatory element-binding protein-1c) and ChREBP (carbohydrate response element-binding protein), respectively, leading to lipogenic pathway activation causing conversion of excess glucose to fatty acids. Here, MLXIPL is linked to metabolic dysfunction-associated steatotic liver disease.