IGHE and asthma: Although the relationship between CD23 and IgE production is interleukin-4-dependent (Reichert, 2004), it has also been reported that sCD23 is increased in allergic diseases such as asthma (Daher et al., 1995; Lorenzo et al., 1996; Richards and Katz, 1997; Rogala and Rymarczyk, 1999).