IgE-mediated immunologic pathways present an attractive target for intervention in asthma and corbidities, including allergic rhinitis, rhinoconjunctivitis, atopic dermatitis, vernal keratoconjunctivitis, chronic rhinosinusitis with nasal polyps, food allergies, and allergic bronchopulmonary aspergillosis (Humbert et al., 2019). The gene discussed is IGHE; the disease is allergic rhinitis.