AKT1 and graft versus host disease: Herrero-Sánchez Ma Carmen et al. revealed that the PI3K/AKT pathway is closely related to the proliferation of T cells in graft-versus-host disease; meanwhile, the ability of pathway inhibitors (BKM120 and BEZ235) to suppress activated T cell proliferation were confirmed (Herrero-Sanchez et al., 2016).