Genes encoding proteins targeted by celastrol are involved in signaling pathways (Figure 4A) including pathways in cancer (hsa05200), PI3K/Akt signaling pathway (hsa04151), fluid shear stress and atherosclerosis (ko05418), Th17 cell differentiation (ko04659), as well as small cell lung cancer (hsa05222). The gene discussed is AKT1; the disease is atherosclerosis.