Genes encoding proteins targeted by celastrol are involved in signaling pathways (Figure 4A) including pathways in cancer (hsa05200), PI3K/Akt signaling pathway (hsa04151), fluid shear stress and atherosclerosis (ko05418), Th17 cell differentiation (ko04659), as well as small cell lung cancer (hsa05222). Here, AKT1 is linked to small cell lung carcinoma.