In view of the results of C-reactive protein levels in previous clinical trials, it was found that there was a difference in inflammation level between NDD and DD patients and DD patients were more likely to be associated with a higher level of inflammation which had a non-ignorable effect on the management of CKD-related anemia (Eustace et al., 2004; Costa et al., 2008; Holdstock et al., 2016; Watanabe et al., 2016; Singh et al., 2021a; Singh et al., 2021b). This evidence concerns the gene CRP and anemia (phenotype).