Various growth factors have been shown to promote endothelial cell proliferation, migration, differentiation, and angiogenesis, such as the vascular endothelial cell growth factor (VEGF) and basic fibroblast growth factor (bFGF), which have been used in the treatment of ischemic diseases (Scharpfenecker et al., 2007; Bir et al., 2014). Here, FGF2 is linked to ischemic disease.